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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal. The ultimate goal of genome editing is to be able to make any specific change to the blueprint of life. A molecule has now been characterized that acts to inhibit a cancer-causing form of KRAS protein and stimulate the immune system.

The inhibitor is one of the first of its kind to show anticancer activity in the clinic. Approximately A previously unknown bacterial toxin has now been characterized. Perspective 06 November This Perspective examines the global production ecosystem through the lenses of connectivity, diversity and feedback, and proposes measures that will increase its stability and sustainability.

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The authors discuss the potential for sex and gender analysis to foster scientific discovery, improve experimental efficiency and enable social equality. Atomic physicists and nuclear physicists have each made a refined measurement of the radius of the proton. Both values agree with a hotly debated result obtained by spectroscopy of an exotic form of hydrogen called muonic hydrogen. Bacteria move along gradients of chemical attractants. Two studies find that, in nutrient-rich environments, bacteria can grow rapidly by following a non-nutritious attractant — but expanding too fast leaves them vulnerable.

Ten pathways for the utilization of carbon dioxide are reviewed, considering their potential scale, economics and barriers to implementation. In , scientists found a previously unseen particle, which is now called a neutral kaon. This work led to the discovery of elementary particles known as quarks, and ultimately to the establishment of the standard model of particle physics.

A Nature paper reported how cell lines could be made that produce an antibody of known specificity. This discovery led to major biological insights and clinical successes in treating autoimmunity and cancer. Distant DNA regions are juxtaposed and joined to form diverse immune-system genes encoding antibodies and T-cell receptors.


It seems that both types of gene form by relying on DNA extrusion through a protein ring called cohesin. A tracer molecule has been used to analyse tumours in vivo in mice and to group cancers according to their metabolic characteristics. Such information could have implications for determining how different malignancies are treated.

An analysis of air up to 2 million years old, trapped in Antarctic ice, shows that a major shift in the periodicity of glacial cycles was probably not caused by a long-term decline in atmospheric levels of carbon dioxide. Data are mounting that document widespread insect losses. A long-term research project now provides the strongest evidence of this so far, and demonstrates the value of standardized monitoring programmes. How Nature reported a ban on artificial sweeteners in , and the growing awareness of vitamins in In , a Nature paper reported an African fossil of a previously unknown genus called Australopithecus.

This finding revolutionized ideas about early human evolution after human ancestors and apes split on the evolutionary tree.

Witness Interviews in Internal Investigations: The UK Perspective

Chemotherapy-treated cancer cells that enter a non-dividing state called senescence can nevertheless boost cancer growth. The finding that these cells eat neighbouring cells reveals a mechanism that enables senescent cells to persist. In , scientists reported the discovery of the cage-like carbon molecule C The finding paved the way for materials such as graphene and carbon nanotubes, and was a landmark in the emergence of nanotechnology.

Immunotherapy treatment harnesses CD8 T cells of the immune system to kill tumour cells. The finding that CD4 helper T cells contribute to the success of this treatment in mice might offer a way to improve clinical outcomes. The unexpected discovery of a hole in the atmospheric ozone layer over the Antarctic revolutionized science — and helped to establish one of the most successful global environmental policies of the twentieth century. A better understanding of the genetic changes that enable cancers to spread is crucial. A comprehensive study of whole-genome sequences from metastatic cancer will help researchers to achieve this goal.

Fossil finds that can provide clues about how aquatic vertebrates evolved into land dwellers are elusive. But the ancient bones of a newly discovered species of tetrapod now provide some crucial missing evidence. Microorganisms in the gut influence fear-related learning.

The results of a study that reveals some of the mechanistic underpinnings of this phenomenon promise to boost our understanding of gut—brain communication.

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The ability of structures called optical resonators to trap light is often limited by scattering of light off fabrication defects. A physical mechanism that suppresses this scattering has been reported that could lead to improved optical devices. Asking to review whatever the editor has on hand sounds a bit desperate and comes off as slightly unprofessional. Finally, reviewers will sometimes submit reviews that do not conform to the formatting expectations of the journal.

This is very annoying as it requires me to send it back to the author for revisions, thus delaying its full consideration and hopefully acceptance into the journal. Can you share with us a publication ethics issue or two you have come across -whether as an editor, reviewer, or fellow researcher who often reads the works of others?

Fortunately, in my time as a book review editor I have seldom come across any issues regarding publication ethics. I sincerely hope that trend persists and I have not jinxed myself or the journal. As a highly efficient qualitative researcher, are there any research tools you have found to be valuable to your research activity?

Despite the fact that I spend a great deal of my time researching technological issues, I am surprisingly analog when it comes to qualitative research. To me, software is only good for organizing and structuring qualitative data. In the past, I have used both Microsoft Excel and the software package Atlas. For the actual analysis itself, I tend to emphasize human interpretation. Some people will use qualitative software programs like nVivo and Atlas.

I tend to shy away from these.

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Since qualitative research is so fundamentally grounded in the dissection and interpretation of human meaning, I am reluctant to let software do any of the work for me beyond data organization. Disclaimer of Endorsement and Liability: Dr. This interview is for informational purposes only and cannot be construed as an endorsement or recommendation for Editage.

Understanding different research perspectives: View as single page

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Industry Opinion. Planning to Write. How do journals evaluate book reviews: Perspectives… How do journals evaluate book reviews: Perspectives from a book…. Gaming of peer review, parenting in academia,… Gaming of peer review, parenting in academia, academics' "guilty…. How journals make assertions: An insight into the… How journals make assertions: An insight into the publishing industry. How do journals evaluate book reviews: Perspectives from a book review editor. Series: Part Interview with Dr. Kevin Steinmetz. Mar 10, Thank you, Dr.

This interview was conducted by Alagi Patel. Continue with Facebook. Signin with Google. Login with Linkedin. Login with Twitter.